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GENERIC NAME: duloxetine Manufacturer: generic cymbalta side effects
DRUG CLASS AND MECHANISM: Duloxetine can be a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used in treating depression, anxiety and pain connected to diabetic peripheral neuropathy or fibromyalgia. Other drugs within this class include milnacipran (Savella), venlafaxine (Effexor), and desvenlafaxine (Pristiq). Duloxetine affects neurotransmitters, the harmful chemicals that nerves from the brain make and release so that they can communicate with 1 another. Neurotransmitters either travel throughout the space between nerves and fix to receptors seems to of nearby nerves or they put on receptors on top of the nerves that produced them, to remain taken up with the nerve and released again (a process referred to as re-uptake).
Most pros think that an imbalance among neurotransmitters is definitely the reason behind depression as well as other psychiatric disorders. Serotonin and norepinephrine are a couple of neurotransmitters released by nerves using the brain. Duloxetine operates preventing the reuptake of serotonin and epinephrine by nerves when they happen to be released. Since uptake is an essential mechanism for removing released neurotransmitters and terminating their actions on adjacent nerves, the lower uptake as a result of duloxetine boosts the effect of serotonin and norepinephrine within the brain. The mechanism responsible for its effectiveness treating pain will not be known but is thought to involve its effects on serotonin and norepinephrine during the brain. Duloxetine was approved by the FDA in August 2004.
PREPARATIONS: Delayed-release capsules: 20, 30, and 60 mg
STORAGE: Capsules need to be stored at room temperature, between 15 to 30 C (59 to 86 F).
PRESCRIBED FOR: Duloxetine is commonly employed for the treatment of depression, generalized panic disorder, and pain linked to diabetic peripheral neuropathy or fibromyalgia.
DOSING: The recommended dose for the treatment of depression is 20 or 30 mg twice daily or 60 mg once daily. Patients may well be began with 30 mg once daily first week ahead of the dose is advanced to 60 mg daily. The recommended dose for panic, pain linked to diabetic neuropathy or fibromyalgia is 60 mg daily. There's no evidence that doses much more than 60 mg/day provide additional benefits.
DRUG INTERACTIONS: Duloxetine mustn't be used in conjunction with a monoamine oxidase inhibitor (MAOI) including phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), and selegiline (Eldepryl), or within A couple weeks of discontinuing the MAOI. At the very least 5 days should really be allowed after stopping duloxetine before commencing an MAOI. Mixtures of SNRIs and MAOIs can result in serious, sometimes fatal, reactions including quite high body temperature, muscle rigidity, rapid fluctuations of pulse and bp, extreme agitation progressing to delirium, and coma. Similar reactions can happen if duloxetine is coupled with antipsychotics, tricyclic antidepressants and other drugs affecting serotonin within the brain (one example is, tryptophan, and sumatriptan (Imitrex).
